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Traditional Library


These Are Our Most Recent Works

  • Kim J, Bose D, Arainga M, Haque MR, Fennessey C, Caddell RA, Thomas Y, Ferrel D, Ali S, Grody E, Goyal Y, Hope TJ, Villinger FJ, Martinelli E. TGF-b blockade drives a transitional effector phenotype in T cells reversing SIV latency and decreasing SIV reservoirs in vivo. (


  • Van Ryk D, Vimonpatranon S, Hiatt J, Ganesan S, Chen N, McMurry J, Garba S, Min S, Goes LR; Girard A, Yolitz J, Licavoli I, Wei D, Huang D, Soares DA, Martinelli E,  Cicala C, Arthos J. The V2 Domain of HIV gp120 Mimics an Interaction Between CD4 and Integrin α4β​7. (Plos Pathogens, In press)


  • Aravantinou M, Plagianos M, Kokogho A, Adebajo S, Nowak RG, Shoyemi E, Ekeh C, Lombardi K, Peel SA, Baral SD, Crowell TA, Derby N, Teleshova N, Martinelli E, TRUST/RV368 Study Group HSV-2 prevalence and association with inflammatory cytokines among sexual and gender minorities (SGM) living with and without HIV-1 from Lagos, Nigeria. (AIDS Research and Human Retroviruses, Feb 23 2023 PMID: 36825536)


  • Samer S, Thomas Y, Araínga M, Carter C, Shirreff LM, Arif MS, Avita JM, Frank I, McRaven M, Thuruthiyil CT, Bose D, Arthos J, Cicala C, Sereti I, Santangelo P, Lorenzo-Redondo R, Hope TJ, Villinger FJ, Martinelli E. Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo. (JCI Insight, 2022 Nov 8. PMID: 36125890)


  • Frank I, Cigoli M, Arif MS, Fahlberg MD, Maldonado S, Calenda G, Pegu A, Yang ES, Rawi R, Chuang GY, Geng H, Liu C, Zhou T, Kwong PD, Arthos J, Cicala C, Grasperge BF, Blanchard JL, Gettie A, Fennessey CM, Keele BF, Vaccari M, Hope TJ, Fauci AS, Mascola JR, Martinelli E. α4β7-blockade delays viral rebound in SHIV-SF162P3 infected macaques treated with anti-HIV broadly neutralizing antibodies. (Science Translational Medicine, Aug 2021 PMDI 34408080)


  • Madden PJ, Arif MS, Becker ME, McRaven MD, Carias AM, Lorenzo-Redondo R, Xiao S, Midkiff CC, Blair RV, Potter EL, Martin-Sancho L, Dodson A, Martinelli E, Todd JM, Villinger FJ, Chanda SK, Aye PP, Roy CJ, Roederer M, Lewis MG, Veazey RS, Hope TJ. Development of an In Vivo Probe to Track SARS-CoV-2 Infection in Rhesus Macaques. (Frontiers Immunology Dec 2021 PMID: 35003140)


  • Wu S, Frank I, Derby N, Martinelli E, Cheng CY. HIV-1 Establishes a Sanctuary Site in the Testis by Permeating the BTB Through Changes in Cytoskeletal Organization. (Endocrinology Nov 1st 2021 PMID: 34343260)


  • S. Yang, G. Arrode-Bruses, I. Frank, B. Grasperge, J. Blanchard, A. Gettie, E. Martinelli*, E. A. Ho* Anti-α4β7 monoclonal antibody-conjugated nanoparticles block integrin α4β7 (Science Advances – Aug 2020 PMDI 32937372.)


  • Carson L, Merkatz R, Martinelli E, Boyd P, Variano B, Sallent T, Malcolm K. The Vaginal Microbiota, Bacterial Biofilms and Polymeric Drug-Releasing Vaginal Rings. (Pharmaceutics – 2021 May 19 PMC8161251).


  • Frank I, Acharya A, Routhu NK, Aravantinou M, Justin L. Harper, Semova S, Mazel S, Paiardini M, Derby N, Byrareddy SN, and Martinelli E.  A Tat/Rev Induced Limiting Dilution Assay to measure the magnitude of inducible viral reservoirs in non-human primate models of HIV infection. (Scientific Reports. Aug 19 2019 PMID: 31427605)


  • Calenda G, Frank I, Arrode-Bruses G, Pegu A, Wang K, Arthos J, Cicala C, Grasperge B, Blanchard J, Maldonado S, Gettie A, Fauci AS, Mascola JR and Martinelli E. Protection against repeated vaginal SHIV challenges by a combination of VRC01 and an anti-α4β7 antibody. (PlosPathogens, May 13 2019 PMID: 31083797)


  • Calenda G, Villegas G, Reis A, Millen L, Barnable P, Mamkina L, Kumar N, Roberts K, Kalir T, Martinelli E, Sperling R, Teleshova N. Mucosal Susceptibility to Human Immunodeficiency Virus Infection in the Proliferative and Secretory Phases of the Menstrual Cycle. (AIDS Res Hum Retroviruses. Feb 6 2019 PMID: 30600686)


  • Derby N, Lal M, Aravantinou M, Kizima L, Barnable P, Rodriguez A, Lai M, Wesenberg A, Ugaonkar S, Mizenina O, Lifson JD, Heneine W, O’Keefe B, Robbiani M, Martinelli E, Grasperge B, Blanchard J, Gettie A, Teleshova N, Fernández-Romero JA, Zydowsky TM. Griffithsin/Carrageenan Fast Dissolving Inserts Prevent SHIV, HSV-2 and HPV Infections in vivo. (Nature Communications. Sept 24 2018 PMID: 30250170)


  • Lertjuthaporn S, Cicala C, Van Ryk D, Liu M, Yolitz J, Wei D, Horowitch B, Lu S, Lou Y, Wang S, Pan R, Jiang X, Morris L, Wibmer C, Biris K, Mason R, Gorman J, Martinelli E, Roederer M, Fujikawa D, Gorini G, Franchini G, Arakelyan A, Ansari AA, Pattanapanyasat K, Kong X-P, Fauci AS, Arthos J. Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to a4b7  (Plos Pathogens Aug 28 2018 PMID: 30153309)


  • Nawaz F, Goes LR, Jocelyn RC, Sajani A, Ansari AA, Van Ryk D, Wei D, Connors M, Migueles SA, Martinelli E, Villinger F, Cicala C, Fauci AS, Arthos J. MadCAM Costimulation Through Integrin a4b7 Promotes HIV Replication (Mucosal Immunology, 2018 Jun 6 PMID: 29875402)


  • Calenda G, Keawvichit R, Arrode-Bruses G, Byrareddy S, Grasperge B, Blanchard J, Gettie A, Ansari A and Martinelli E. Integrin α4β7 Blockade Preferentially Impacts CCR6+ Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques. (J Immunology Dec 1 2017; PMID: 29196458).


  • Aravantinou M, Mizenina O, Calenda G, Kenney J, Frank I, Lifson J, Szpara M, Grasperge B, Blanchard J, Gettie A, Martinelli E., Derby N. Experimental Oral Herpes Simplex Virus-1 (HSV-1) Co-infection in Simian Immunodeficiency Virus (SIV)-Infected Rhesus Macaques. (Front. Microbiol. 2017 Dec 5; PMID: 29259582).


  • Aravantinou M , Frank I, Arrode-Bruses G, Szpara M, Grasperge B,  Blanchard J, Gettie A, Derby N, Martinelli E. A model of genital herpes simplex virus Type 1 infection in Rhesus Macaques. (J Medical Primatology 2017 July 27 PMID: 28748667).


  • Arrode-Bruses G, Frank I, Goode D, Truong R, Blanchard J, Gettie A, Kleinbeck Kyle, Zydowsky T, Martinelli E. A small molecule, which competes with MAdCAM-1, activates integrin α4β7and fails to prevent mucosal transmission of SHIV-SF162P3 (Plos Pathogens. 2016 June 27; PMID 27348748).


  • Guerra-Perez N, Aravantinou M, Veglia F, Blanchard J, Gettie A, Robbiani M, Martinelli E. Rectal HSV-2 infection increases rectal SIV acquisition even in the context of SIVΔnef vaccination (PlosOne 2016; PMID: 26886938).



  • Guerra-Perez N, Frank I, Veglia F, Aravantinou M, Goode D, Blanchard J, Gettie A, Robbiani M, Martinelli E. Retinoic Acid imprints a mucosal-like phenotype on dendritic cells with an increased ability to fuel HIV-1 Infection. (J. Immunology. 2015 Mar 1; PMID: 25624458).


  •    Goode D, Truong R, Villegas G, Calenda G, Guerra-Perez N, Piatak M, Lifson JD, Blanchard J, Gettie A, Robbiani M, Martinelli E. HSV-2-driven increase in the expression of a4b7 correlates with increased susceptibility to vaginal SHIVSF162P3 infection (Plos Pathogens, 2014 Dec 18; PMID: 25521298).


  • Goode D, Aravantinou M, Jarl S, Truong, Derby N, Guerra-Perez N, Kenney J, Blanchard J, Gettie A, Robbiani M and Martinelli E. Sex hormones selectively impact the endocervical mucosal microenvironment: implication for HIV transmission. (Plos One. May 2014 5; PMID: 24830732)


  • Martinelli E, Derby N, Robbiani M. Nonhuman Primate Models of HIV transmission. Book Chapter  Encyclopedia of AIDS (Springer 2014)


  • Martinelli E, Veglia F, Goode D, Guerra-Perez N, Aravantinou M, Arthos J, Piatak M, Lifson DJ, Blanchard J, Gettie A and Robbiani M. The frequency of α4β7high memory CD4+ T cells correlates with susceptibility to SIV rectal infection. (Journal of AIDS. 2013 Dec 1; ; PMID: 23797688)


  • Teleshova N, Derby, Martinelli E, Pugach P, Calenda G, Robbiani M, Wu L, Schwartz O. Simian immunodeficiency virus interactions with macaque dendritic cells. Chapter from: HIV interactions with dendritic cells: Infection and immunity. (Adv Exp Med Biol. 2013; PMID: 22975875)


  • Zou Z, Chastain A, Moir S, Ford J, Trandem K, Martinelli E, Cicala C, Crocker C, Arthos J, Sun PD. Siglecs. Facilitate HIV-1 Infection of Macrophages through Adhesion with Viral Sialic Acids. (PLoS One. Sept 2011; PMID: 21931755)


  • Derby N, Martinelli E, Robbiani M.  Myeloid dendritic cells in HIV-1 infection (Curr Opin HIV AIDS. Jul 7 2011)


  • Martinelli E, Tharinger H, Frank I, Arthos J, Piatak M Jr, Lifson JD, Blanchard J, Gettie A, Robbiani M.  Infection of Dendritic Cells Amplifies a Highly Susceptible HIV-1 Cell Target. (PLoS Pathog. Jun 2011;7(6):e1002109)


  • Alger J, Becerra-Posada F, Kennedy A, Martinelli E, Cuervo LG, Grupo Colaborativo della Primera Conferencia Latinoamericana de Investigacion para la Salud National health research systems in Latin America: a 14-country review (Rev Panam Salud Publica Nov 26 2009, PMDI:20107697)


  • Cicala C*, Martinelli E* McNally J, Goode D, Gopaul R, Hiatt J, Jelicica K, Kottilil S, Macleod K, O’Sheaa A, Patel N, Van Ryk D, Wei D, Pascuccio M, Yib L, McKinnonc L, Izullad P, Kimani J, Kaul R, Fauci A, Arthos J. The Integrin a4b7 Forms a Complex with Cell-Surface CD4 and Defines a T Cell Subset that is Highly Susceptible to Infection by HIV-1 (Proc Natl Acad Sci. 2009 Nov; 20) *equal 1st authors


  • Arthos J*, Cicala C*, Martinelli E*, Macleod K, Van Ryk D, Wei D, Xiao Z, Veenstra T, Conrad T, Lempicki R, Cruz C, Censoplano N, Chung E, Reitano K, Kottilil S, Goode D, Fauci AS. HIV-1 envelope binds to, and signals through integrin α4β7, the gut mucosal homing receptor (Nat Immunology 2008; 9: 301-309)  *equal 1st authors


  • Martinelli E, Cicala C, Van Ryk D, Goode D, Macleod K, Arthos J, Fauci AS. HIV-1 gp120 Inhibits TLR9 Mediated Activation and IFN-a secretion in Plasmacytoid Dendritic Cells. (Proc Natl Acad Sci. 2007 (Feb 27) 104(9): 3396-401)


  • Cicala C, Arthos J, Martinelli E, Censoplano N, Cruz CC, Chung E, Fauci AS. R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cells. (Proc Natl Acad Sci U S A. 2006 (Mar 7); 103(10): 3746-51)


  • Ahlqvist J, Donati D, Martinelli E, Akhyani N, Hou J, Major EO, Jacobson S, Fogdell-Hahn A. Complete replication cycle and acquisition of tegument in nucleus of human herpesvirus 6A in astrocytes and in T-cells. (J Med Virol. 2006 Dec; 78(12): 1542-53)



  • Cassiani-Ingoni R, Greenstone HL, Donati D, Fogdell-Hahn A, Martinelli E, Refai D, Martin R, Berger EA, Jacobson S. CD46 on glial cells can function as a receptor for viral glycoprotein-mediated cell-cell fusion. (Glia. 2005 Nov 15; 52(3): 252-8)


  • Martinelli E, Donati D, Cassiani-Ingoni R, Ahlqvist J, Hou J, Major EO, Jacobson S. Variant-specific tropism of human herpesvirus 6 in human astrocytes. (J Virol. 2005 Aug; PMID: 16014907)

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